Miach P J, Dawborn J K, Louis W J, McDonald I G
Clin Nephrol. 1981 May;15(5):259-63.
Echocardiographic assessment of left ventricular function was performed in twenty-two unselected patients on stable, chronic maintenance dialysis. The statistically significant abnormalities were enlargement of the left ventricular cavity (end diastolic internal dimension or "diameter" 5.4 +/- 0.2 cm, normal 4.4 +/- 0.3 cm), thickening of the left ventricular wall (end diastolic thickness 1.1 +/- 0.05 cm, normal 0.9 +/- 0.03 cm) and a reduction in myocardial contraction (fractional shortening 28.2 +/- 2.0%, normal 35.7 +/- 0.9%). Myocardial impairment could not be attributed to the effects of hypertension or to ischemic heart disease. There was, however, a significant negative correlation between fractional shortening and total plasma catecholamines (r = 0.45, P less than 0.05) suggesting that excessive catecholamines may contribute to the decreased myocardial contraction seen in uremic patients.
对22例未经挑选的、进行稳定的慢性维持性透析的患者进行了超声心动图左心室功能评估。具有统计学意义的异常包括左心室腔扩大（舒张末期内径或“直径”为5.4±0.2厘米，正常为4.4±0.3厘米）、左心室壁增厚（舒张末期厚度为1.1±0.05厘米，正常为0.9±0.03厘米）以及心肌收缩力降低（缩短分数为28.2±2.0%，正常为35.7±0.9%）。心肌损伤不能归因于高血压或缺血性心脏病的影响。然而，缩短分数与血浆总儿茶酚胺之间存在显著的负相关（r = 0.45，P < 0.05），这表明过多的儿茶酚胺可能导致尿毒症患者心肌收缩力下降。
