Hosenpud J D, Norman D J, Cobanoglu M A, Floten H S, Conner R M, Starr A
Division of Cardiology, Oregon Health Sciences University, Portland 97201.
J Heart Transplant. 1987 Nov-Dec;6(6):343-7.
Serial M-mode and two-dimensional echocardiograms were performed on 10 patients at 1 week, 1 month, and 3 months after heart transplantation to determine early structural and functional changes in the allograft. Standard M-mode echocardiographic measurements of at least five cardiac cycles were averaged. Right ventricular size and function were assessed by mid-ventricular diameter and the right ventricular apex to lateral tricuspid anulus shortening fraction, respectively, on the two-dimensional apical four-chamber view. There were no consistent differences in left ventricular end-diastolic dimension or fractional shortening between study periods. Left ventricular posterior wall thickness decreased from 15 +/- 2 to 11 +/- 1 mm (p = 0.001), and septal thickness decreased from 15 +/- 2 to 12 +/- 2 mm (p = 0.0006) between the 1-week and 3-month studies. Right ventricular cross-sectional dimension increased from 34 +/- 6 to 39 +/- 6 mm (p = 0.047), and right ventricular fractional shortening increased from 13% +/- 3% to 21% +/- 5% (p = 0.0051) between the 1-week and 3-month studies. There were no correlations between any of the above changes and rejection episodes. There was a weak correlation (r = 0.53) between ischemic time and change in posterior wall thickness. Right ventricular dysfunction and increased left ventricular wall thickness presumably caused by interstitial edema appear to be normal findings early after heart transplantation.
对10例心脏移植患者在术后1周、1个月和3个月进行系列M型和二维超声心动图检查，以确定同种异体移植物早期的结构和功能变化。对至少五个心动周期的标准M型超声心动图测量值进行平均。在二维心尖四腔视图上，分别通过心室中部直径和右心室心尖至三尖瓣环外侧缩短分数评估右心室大小和功能。各研究期间左心室舒张末期内径或缩短分数无一致差异。在1周和3个月的研究之间，左心室后壁厚度从15±2毫米降至11±1毫米（p = 0.001），室间隔厚度从15±2毫米降至12±2毫米（p = 0.0006）。在1周和3个月的研究之间，右心室横截面积从34±6毫米增加至39±6毫米（p = 0.047），右心室缩短分数从13%±3%增加至21%±5%（p = 0.0051）。上述任何变化与排斥反应发作之间均无相关性。缺血时间与后壁厚度变化之间存在弱相关性（r = 0.53）。右心室功能障碍和可能由间质水肿引起的左心室壁厚度增加似乎是心脏移植术后早期的正常表现。
