小鼠出生后发育过程中抑制机制的变化。
Changes in suppressor mechanisms during postnatal development in mice.
作者信息
Calkins C E, Stutman O
出版信息
J Exp Med. 1978 Jan 1;147(1):87-97. doi: 10.1084/jem.147.1.87.
The activity of suppressor cells from spleens of mice of varying ages was assessed by their addition to cultures of normal or SRBC immune spleen cells together with a challenge of SRBC. 1-wk and adult spleen cells were highly suppressive of the secondary in vitro antibody response to SRBC. 3-wk spleen cells were less active in suppressing this response. The nature of the suppression and the character of the suppressor cells changed in this period. Whereas adult spleen cells demonstrated specificity, 1-wk cells nonspecifically suppressed all responses tested. Further, unlike adult suppressor cells (which are Thy.1.2 positive), 1-wk suppressor cells are insensitive to anti-Thy.1.2 treatment in this system. Both cells are nonadherent to glass beads and nylon wool and are undetectable in the normal thymus.
通过将不同年龄小鼠脾脏中的抑制细胞添加到正常或经绵羊红细胞（SRBC）免疫的脾细胞培养物中，并同时用SRBC进行刺激，来评估这些抑制细胞的活性。1周龄和成年小鼠的脾细胞对体外针对SRBC的二次抗体反应具有高度抑制作用。3周龄小鼠的脾细胞在抑制这种反应方面活性较低。在此期间，抑制的性质和抑制细胞的特性发生了变化。成年脾细胞表现出特异性，而1周龄的细胞则非特异性地抑制所有测试的反应。此外，与成年抑制细胞（Thy.1.2阳性）不同，在该系统中，1周龄的抑制细胞对抗Thy.1.2处理不敏感。两种细胞均不黏附于玻璃珠和尼龙棉，且在正常胸腺中无法检测到。
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