Mouton R P, Bongaerts G P, van Gestel M, Bruggeman-Ogle K M
Chemotherapy. 1981;27(5):318-24. doi: 10.1159/000237999.
Comparison of the activity of cefoperazone, cefamandole, cefotaxime, cephalothin and moxalactam against Enterobacteriaceae showed cefoperazone to be twofold (Escherichia coli, Klebsiella) to eigthfold (Enterobacter) more active than cefamandole. The lowes MIC values were found for cefotaxime (0.03 - 0.25 microgram/ml) followed by moxalactam (0.06 - 0.25 microgram/ml). Cefoperazone stood out in activity against Pseudomonas aeruginosa (MIC50 4 microgram/ml). Cephalothin resistance affected the MIC values of cefoperazone and moxalactam only to a small degree. From beta-lactamase susceptibility studies it was concluded that cefoperazone may be hydrolyzed by TEM type beta-lactamases, but that the cephalosporinases (class I) and the chromosomal broad-spectrum beta-lactamases (class IV) only have little effect on this antibiotic. Moxalactam was not degraded by any of the beta-lactamase preparations tested.
头孢哌酮、头孢孟多、头孢噻肟、头孢噻吩和拉氧头孢对肠杆菌科细菌活性的比较表明，头孢哌酮的活性比头孢孟多高两倍（大肠杆菌、克雷伯菌属）至八倍（肠杆菌属）。头孢噻肟的最低抑菌浓度（MIC）值最低（0.03 - 0.25微克/毫升），其次是拉氧头孢（0.06 - 0.25微克/毫升）。头孢哌酮对铜绿假单胞菌的活性突出（MIC50为4微克/毫升）。头孢噻吩耐药性仅对头孢哌酮和拉氧头孢的MIC值有较小影响。从β-内酰胺酶敏感性研究得出的结论是，头孢哌酮可能被TEM型β-内酰胺酶水解，但头孢菌素酶（I类）和染色体广谱β-内酰胺酶（IV类）对这种抗生素影响很小。拉氧头孢未被所测试的任何一种β-内酰胺酶制剂降解。
