Thabaut A, Durosoir J L, Saliou P
Chemotherapy. 1981;27 Suppl 1:19-24. doi: 10.1159/000238024.
The in vitro activity of 8 cephalosporins - cephalothin, cefamandole, cefoxitin, cefuroxime, cefotaxime, cefoperazone, moxalactam and ceftriaxone (Rocephin) was studied on 109 strains of Neisseria gonorrhoeae and 60 strains of Neisseria meningitidis, isolated from pathological material. Determination of the MICs of these antibiotics by an agar dilution method shows that on N. gonorrhoeae ceftriaxone (geometric mean of the MICs: 0.0008 microgram/ml) is the most active, followed by cefotaxime (0.001 microgram/ml); cefoperazone (0.008 microgram/ml) and moxalactam (0.01 microgram/ml) are one-tenth as active; then come cefuroxime (0.05 microgram/ml), cefamandole (0.10 microgram/ml) and finally cephalothin (0.26 microgram/ml) and cefoxitin (0.26 microgram/ml). The least susceptibility to penicillin and, to a greater degree, the production of beta-lactamase (8 strains) affect the level of susceptibility to these cephalosporins, but the MICs always remain relatively low.
对从病理材料中分离出的109株淋病奈瑟菌和60株脑膜炎奈瑟菌，研究了8种头孢菌素——头孢噻吩、头孢孟多、头孢西丁、头孢呋辛、头孢噻肟、头孢哌酮、拉氧头孢和头孢曲松（罗氏芬）的体外活性。通过琼脂稀释法测定这些抗生素的最低抑菌浓度（MIC）表明，对淋病奈瑟菌而言，头孢曲松（MIC的几何平均值：0.0008微克/毫升）活性最强，其次是头孢噻肟（0.001微克/毫升）；头孢哌酮（0.008微克/毫升）和拉氧头孢（0.01微克/毫升）的活性为前者的十分之一；然后是头孢呋辛（0.05微克/毫升）、头孢孟多（0.10微克/毫升），最后是头孢噻吩（0.26微克/毫升）和头孢西丁（0.26微克/毫升）。对青霉素的最低敏感性以及更大程度上β-内酰胺酶的产生（8株）影响了对这些头孢菌素的敏感水平，但MIC始终相对较低。
