组胺及组胺拮抗剂对人体胃酸分泌和黏膜血流的影响。
The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man.
作者信息
Knight S E, McIsaac R L, Rennie C D
出版信息
Br J Surg. 1980 Apr;67(4):266-8. doi: 10.1002/bjs.1800670412.
Abstract
Histamine has been investigated for its effect on gastric acid secretion and mucosal blood flow in man. Dose-response curves were constructed and analysed in the presence of H1- and H2-antagonists. Mepyramine had no effect on acid secretion or mucosal blood flow. Cimetidine reduced acid secretion but had no effect on blood flow. This suggests that the vasculature is less sensitive to cimetidine than the parietal cell.
摘要
组胺对人体胃酸分泌和黏膜血流的影响已得到研究。在存在H1和H2拮抗剂的情况下构建并分析了剂量反应曲线。甲氧苄二胺对胃酸分泌或黏膜血流无影响。西咪替丁可减少胃酸分泌，但对血流无影响。这表明血管系统对西咪替丁的敏感性低于壁细胞。
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