Alarcón-Segovia D, Palacios R
Arthritis Rheum. 1981 Aug;24(8):1086-92. doi: 10.1002/art.1780240818.
We studied T cell surface markers, concanavalin A-induced, and spontaneously expanded suppressor cell function and the functions of postthymic precursor (Tar) cells in 3 patients with diphenylhydantoin (DPH)-related systemic lupus erythematosus (SLE). The findings were compared with those in 6 patients with spontaneously occurring SLE, 3 with active and 3 with inactive disease as well as with those in 3 normal volunteers. All 4 groups were age and sex matched. Findings were also compared to studies made in a group of 32 untreated idiopathic SLE patients and 32 normal controls. All T cell markers and immunoregulatory functions were normal in the DPH-treated SLE patients whereas all groups of patients with spontaneously occurring SLE had low numbers of t gamma cells, and Tar cells, and decreased concanavalin-A and spontaneously expended suppressor, human feedback inhibition and generation of suppression functions. Since consanguineous relatives of patients with spontaneously occurring SLE have been shown to have decreased suppressor cell function and patients with long-inactive spontaneous SLE continue to have defects in their T cell circuits, our findings may indicate that, in patients who develop SLE upon DPH intake the lupus diathesis uncovered by the drug probably resides in a site of immunoregulation different from that involved in spontaneously occurring lupus.
我们研究了3例与苯妥英（DPH）相关的系统性红斑狼疮（SLE）患者的T细胞表面标志物、刀豆蛋白A诱导的和自发扩增的抑制细胞功能以及胸腺后前体（Tar）细胞的功能。将这些结果与6例自发性SLE患者（3例活动期和3例非活动期）以及3例正常志愿者的结果进行了比较。所有4组在年龄和性别上相匹配。研究结果还与一组32例未经治疗的特发性SLE患者和32例正常对照的研究结果进行了比较。接受DPH治疗的SLE患者的所有T细胞标志物和免疫调节功能均正常，而所有自发性SLE患者组的γT细胞和Tar细胞数量均较低，刀豆蛋白A和自发扩增的抑制细胞、人体反馈抑制以及抑制功能的产生均降低。由于自发性SLE患者的近亲已被证明抑制细胞功能降低，且长期非活动的自发性SLE患者的T细胞回路仍存在缺陷，我们的研究结果可能表明，在摄入DPH后发生SLE的患者中，药物揭示的狼疮素质可能存在于与自发性狼疮不同的免疫调节部位。
