Belykh A G
Farmakol Toksikol. 1981 May-Jun;44(3):322-6.
The cholecystographic radiopaque agents, adipiodon and endographin, unlike the urographic contrast agents, triombrin and iodamide, decrease the fluorescence intensity of hydrophobic probes 1-anilinonaphthalene-8-sulfonate and 4-dimethylaminochalcone in plasmic membranes (PM) of rat hepatocytes primarily at the expense of the lowering of the constant of probe association with the membranes. The similar but less marked effects were discovered in experiments with lecithin lyposomal preparations. As regards the intensity of action, cardiotrast and triotrast an intermediate position between the two groups of radiographic contrast agents. Adipiodon and endographin induce an inhibition of membranous Mg+2 (Na+, K+) ATPase, which correlates with their effect on the structure of the hepatocyte PM. The data obtained allow a conclusion that, unlike the urographic agents, the cholecystographic radiopaque agents are bound to the definite areas of the hepatocytic PM and provoke alterations in the activity of membranous APTase because of the conformational rearrangements of the membranes.
与尿路造影剂泛影葡胺和碘酰胺不同，胆囊造影不透射线剂碘番酸和恩多瑞芬主要通过降低探针与大鼠肝细胞质膜（PM）结合常数，来降低疏水探针1-苯胺基萘-8-磺酸盐和4-二甲基氨基查耳酮在质膜中的荧光强度。在卵磷脂脂质体制剂实验中也发现了类似但不太明显的效果。就作用强度而言，心影葡胺和泛影酸钠在两组造影剂之间处于中间位置。碘番酸和恩多瑞芬会抑制膜性Mg+2（Na+，K+）ATP酶，这与其对肝细胞质膜结构的影响相关。所得数据表明，与尿路造影剂不同，胆囊造影不透射线剂与肝细胞质膜的特定区域结合，并由于膜的构象重排而引起膜性ATP酶活性的改变。
