Hirota Y, Vainio O, Toivanen P
Acta Pathol Microbiol Scand C. 1981 Feb;89(1):35-41. doi: 10.1111/j.1699-0463.1981.tb02662.x.
Effect of surgical bursectomy on antibody response was studied in chicks injected intrabursally with sheep red blood cells (SRBC) and Brucella abortus on day 2 of life and challenged intravenously with the same antigens on day 9. Bursectomy performed 2 days after the priming resulted in a significantly decreased anti-SRBC plaque-forming cell (PFC) response, whereas bursectomy performed 4 or 5 days after the priming clearly enhanced the PFC response. The enhancing effect of bursectomy on the PFC response was also observed if the priming was made intravenously. In antibody titers against SRBC the enhancing effect was observed only if a secondary and tertiary challenge was performed at the age of 28 and 36 days, respectively. Titers of Brucella antibodies were either reduced by the bursectomy (performed 2 or 4 days after the intrabursal priming) or left unaffected (bursectomy performed 5 days after the priming). These findings are discussed in relation to bursa-derived suppressor cells.
研究了手术切除法氏囊对抗体反应的影响。在雏鸡出生第2天通过法氏囊内注射绵羊红细胞（SRBC）和流产布鲁氏菌进行致敏，第9天静脉注射相同抗原进行激发。初次免疫后2天进行法氏囊切除导致抗SRBC空斑形成细胞（PFC）反应显著降低，而初次免疫后4或5天进行法氏囊切除则明显增强了PFC反应。如果初次免疫通过静脉注射进行，也观察到法氏囊切除对PFC反应的增强作用。在抗SRBC抗体效价方面，仅当分别在28天和36天龄时进行二次和三次激发时才观察到增强作用。法氏囊切除（在法氏囊内初次免疫后2或4天进行）使布鲁氏菌抗体效价降低，或（初次免疫后5天进行法氏囊切除）使其不受影响。结合法氏囊来源的抑制细胞对这些发现进行了讨论。
