Pryjma J, Miklaszewska J
Arch Immunol Ther Exp (Warsz). 1981;29(3):331-6.
Induction of the immunoglobulin production by pokeweed mitogen (PWM) and S. aureus. Cowan I has been evaluated in cultures of human peripheral blood mononuclear cells gradually depleted of adherent cells. Partial depletion cells (monitoglobulins while almost complete depletion caused decreased production. These results suggest that an optimal balance of monocytes to lymphocytes is essential in the triggering of immunoglobulin production by human mononuclear cells (MNC) in vitro and that normal monocytes, when in excess, suppress in vitro differentiation of B lymphocytes into immunoglobulin secreting cells.
用商陆有丝分裂原（PWM）和金黄色葡萄球菌考恩I诱导免疫球蛋白产生的情况已在逐渐去除贴壁细胞的人外周血单个核细胞培养物中进行了评估。部分去除贴壁细胞的培养物（产生）单球蛋白，而几乎完全去除贴壁细胞则导致产生减少。这些结果表明，单核细胞与淋巴细胞的最佳平衡对于体外人单个核细胞（MNC）触发免疫球蛋白产生至关重要，并且正常单核细胞过多时会抑制B淋巴细胞在体外分化为免疫球蛋白分泌细胞。
