Strender L E, Blomgren H, Petrini B, Wasserman J, Forsgren M, Norberg R, Baral E, Wallgren A
Cancer. 1981 Nov 1;48(9):1996-2002. doi: 10.1002/1097-0142(19811101)48:9<1996::aid-cncr2820480915>3.0.co;2-m.
A group of 17 patients, having undergone modified radical mastectomy for breast cancer, received 12 cycles of chemotherapy with methotrexate, 5-fluorouracil, and chlorambucil during 17 months. The number of circulating T and non T lymphocytes, as defined by E, EAC, and ME rosette formation, were reduced during treatment. The Non-T lymphocytes, however, were reduced to the highest relative extent. Relative phytohemagglutinin and mixed lymphocyte culture responses of the cells decreased, whereas purified protein derivative responses were unchanged. Serum concentrations of IgM were reduced, but IgA and IgG concentrations were unchanged or slightly increased. Antibody titres to morbilli and herpes simplex were not changed, whereas the antibody activity against cytomegalovirus (CMV) increased in several seropositive patients. None of these patients, however, developed signs of a CMV infection.
一组17例因乳腺癌接受改良根治性乳房切除术的患者，在17个月内接受了12个周期的甲氨蝶呤、5-氟尿嘧啶和苯丁酸氮芥化疗。治疗期间，通过E、EAC和ME玫瑰花结形成所定义的循环T淋巴细胞和非T淋巴细胞数量减少。然而，非T淋巴细胞减少的相对程度最高。细胞的相对植物血凝素和混合淋巴细胞培养反应降低，而纯化蛋白衍生物反应未改变。血清IgM浓度降低，但IgA和IgG浓度未改变或略有升高。麻疹和单纯疱疹抗体滴度未改变，而几名血清阳性患者针对巨细胞病毒（CMV）的抗体活性增加。然而，这些患者均未出现CMV感染迹象。
