自体细胞诱导的淋巴细胞转化。十一、年龄对自体混合淋巴细胞反应的影响。
Lymphocyte transformation induced by autologous cells. XI. The effect of age on the autologous mixed lymphocyte reaction.
作者信息
Moody C E, Innes J B, Staiano-Coico L, Incefy G S, Thaler H T, Weksler M E
出版信息
Immunology. 1981 Oct;44(2):431-8.
The autologous mixed lymphocyte reaction (MLR) was lower in newborn infants and healthy subjects over 65 years of age than in adults between the ages of 20 and 32. In contrast, the allogeneic MLR, although impaired in newborn infants, was normal in elderly subjects. The degree of impairment of the autologous MLR in elderly subjects was correlated with the impairment in the response of lymphocytes from elderly subjects to phytohaemagglutinin (PHA) and Staphylococcus aureus proteins A (SPA). The percentage of autorosetting T cells and of T cells with the OKT4 phenotype was increased in elderly subjects. These findings are paradoxical as autoreactive T cells in young adults have been reported to be drawn from these two T-cell subpopulations.
自体混合淋巴细胞反应（MLR）在新生儿和65岁以上健康受试者中低于20至32岁的成年人。相比之下，同种异体MLR虽然在新生儿中受损，但在老年受试者中正常。老年受试者自体MLR的受损程度与老年受试者淋巴细胞对植物血凝素（PHA）和金黄色葡萄球菌A蛋白（SPA）反应的受损相关。老年受试者中自身凝集T细胞和具有OKT4表型的T细胞百分比增加。这些发现是自相矛盾的，因为据报道，年轻成年人中的自身反应性T细胞来自这两个T细胞亚群。
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