Fernandez L A, MacSween J M
Mech Ageing Dev. 1980 Mar;12(3):245-8. doi: 10.1016/0047-6374(80)90047-0.
The responses of T cells to autologous non-T mononuclear cells is called the autologous mixed lymphocyte reaction (AMLR). It seems to be an immunological response, as there is evidence of both immunologic specificity and memory. The AMLR is absent in systemic lupus erythematosis and chronic lymphocytic leukemia, and our data in normal human show that AMLR decreases with aging. Reactive T cells in the AMLR are subsequently cytotoxic to autologous B cells. We propose that the AMLR may be a protective phenomenon particularly against aberrant or neoplastic clones of B cells; and its decrease in the elderly may play an important permissive role for the development of either increased autoantibodies and/or B cell neoplasias.
T细胞对自体非T单核细胞的反应被称为自体混合淋巴细胞反应（AMLR）。这似乎是一种免疫反应，因为有免疫特异性和记忆的证据。系统性红斑狼疮和慢性淋巴细胞白血病中不存在AMLR，我们在正常人体内的数据表明，AMLR会随着年龄的增长而降低。AMLR中的反应性T细胞随后对自体B细胞具有细胞毒性。我们提出，AMLR可能是一种保护性现象，特别是针对B细胞的异常或肿瘤性克隆；而其在老年人中的降低可能对自身抗体增加和/或B细胞肿瘤的发生发展起到重要的促进作用。
