Murata H, Yata J
Asian Pac J Allergy Immunol. 1986 Dec;4(2):95-9.
We studied the suppressor cell activity induced by concanavalin A (Con A) in 9 patients with acute febrile juvenile rheumatoid arthritis (JRA). The suppressor activity of JRA patients was higher than that of normal controls. However, the activity was significantly reduced by treating Con A-activated cells with mitomycin C (MMC) (P less than 0.05). On the other hand, the suppressor activity of normal controls and systemic lupus erythematosus (SLE) patients was not affected by MMC treatment. Two of 5 SLE patients showed low activity even before MMC treatment. The addition of the culture supernatant of Con A-stimulated peripheral blood mononuclear cells from a normal donor restored the induction of suppressor activity of JRA which was decreased by MMC treatment. The results indicated that patients with acute febrile type of JRA had reduced MMC resistant suppressor cell activity and that this was due to a defect in the ability of the cells to produce soluble factors needed to induce MMC resistant suppressor cells.
我们研究了9例急性发热型幼年类风湿性关节炎（JRA）患者中伴刀豆球蛋白A（Con A）诱导的抑制细胞活性。JRA患者的抑制活性高于正常对照。然而，用丝裂霉素C（MMC）处理Con A激活的细胞后，该活性显著降低（P<0.05）。另一方面，正常对照和系统性红斑狼疮（SLE）患者的抑制活性不受MMC处理的影响。5例SLE患者中有2例在MMC处理前活性就较低。添加来自正常供体的Con A刺激的外周血单个核细胞的培养上清液可恢复因MMC处理而降低的JRA抑制活性的诱导。结果表明，急性发热型JRA患者的MMC抗性抑制细胞活性降低，这是由于细胞产生诱导MMC抗性抑制细胞所需的可溶性因子的能力存在缺陷。
