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[冠状动脉腔内血管成形术。初步结果]

[Transluminal angioplasty of the coronary vessels. Preliminary results].

作者信息

Marco J, Gouel Y, Fournial G, Alibelli M J, Bernies M, Berthoumieu F, Bernadet P

出版信息

Arch Mal Coeur Vaiss. 1981 Oct;74(10):1131-41.

PMID:6458254
Abstract

Transluminal coronary angioplasty is a new therapeutic procedure perfected by Gruntzig in 1977 consisting of compressing atheromatous plaques and dilating the arterial lumen with an inflatable balloon-tipped catheter of fixed external diameter. This catheter is introduced into the coronary artery through a preformed catheter guide under radioscopic control. The authors describe their experience of 36 attempts at coronary angioplasty performed over a one year period. The stenosis was catheterised in 30 cases and a good immediate result was obtained in 28 patients (77%). The percentage narrowing was reduced from an average of 79 +/- 8% to 26 +/- 12% (p less than 0.001) and the trans stenotic gradient from 40 +/- 11 mm Hg to 4 +/- 8 mm Hg (p less than 0.001). No serious complications were observed during these procedures. The 8 other patients underwent aorto-coronary bypass surgery as an emergency (2 cases) or otherwise (5 cases). 26 patients with good immediate results are asymptomatic at medium term follow-up, 1 has improved from functional Class IV to II, and I has recurrent Class IV effort angina. 15 patients have been followed up after six months. 14 remain asymptomatic with negative maximal exercise stress testing; 1 has angina. 14/15 stenoses remain dilated, 1 stenosis has progressed (60%). 2 patients developed a new stenosis, 1 of whom underwent another angioplasty procedure (functional Class III). In the 13 remaining patient, clinical improvement was confirmed by exercise stress testing. With strict selection of patients and a prudent operative technique this method seems to be an attractive intermediate therapeutic procedure (over 60% good results at medium term) between medical and surgical management of patients with severe angina and a tight monotruncular stenosis.

摘要

经腔冠状动脉血管成形术是1977年由格伦齐格完善的一种新的治疗方法,该方法是用一个外径固定的带气囊导管压缩动脉粥样硬化斑块并扩张动脉管腔。此导管在X线透视控制下通过一个预制的导管引导器被插入冠状动脉。作者描述了他们在一年时间里进行36次冠状动脉血管成形术尝试的经验。30例患者的狭窄部位被插入导管,28例患者(77%)立即取得了良好效果。狭窄百分比平均从79±8%降至26±12%(p<0.001),跨狭窄梯度从40±11mmHg降至4±8mmHg(p<0.001)。在这些操作过程中未观察到严重并发症。另外8例患者作为急诊(2例)或其他情况(5例)接受了主动脉冠状动脉搭桥手术。26例立即取得良好效果的患者在中期随访时无症状,1例从功能IV级改善至II级,1例有IV级劳力性心绞痛复发。15例患者在六个月后接受了随访。14例无症状,运动负荷试验结果为阴性;1例有心绞痛。14/15处狭窄仍保持扩张状态,1处狭窄进展(60%)。2例患者出现新的狭窄,其中1例接受了另一次血管成形术(功能III级)。在其余13例患者中,运动负荷试验证实了临床改善。通过严格挑选患者并采用谨慎的手术技术,这种方法似乎是一种有吸引力的介于内科治疗和外科治疗之间的中间治疗方法(中期良好效果超过60%),适用于患有严重心绞痛和紧密单支狭窄的患者。

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