Chen S N, Duquesnoy R J
Clin Exp Immunol. 1981 May;44(2):278-86.
In chessboard mixed leucocyte culture (MLR) experiments we have identified three unrelated healthy blood donors of lymphocytes which showed low stimulatory capacity with apparently MLR-incompatible and HLA-D-non-identical responder lymphocytes. This was due to increased sensitivity to X-irradiation of stimulators which was demonstrable in both MLR and secondary PLT responses. On the other hand, lymphocytes from these donors exhibited normal radiosensitivity when tested as responders in MLR and phytohaemagglutinin- and pokeweed mitogen-induced blastogenesis. The results of family studies of a low stimulator donor suggested that the radiosensitivity of stimulator cells may be under some genetic control which is probably not linked to HLA.
在棋盘式混合淋巴细胞培养（MLR）实验中，我们鉴定出了三名不相关的健康淋巴细胞供血者，他们的淋巴细胞对明显MLR不相容且HLA - D不相同的反应性淋巴细胞的刺激能力较低。这是由于刺激细胞对X射线的敏感性增加，这在MLR和二次血小板反应中都得到了证实。另一方面，当这些供血者的淋巴细胞在MLR以及植物血凝素和商陆有丝分裂原诱导的细胞增殖反应中作为反应细胞进行测试时，表现出正常的放射敏感性。对一名低刺激能力供血者的家系研究结果表明，刺激细胞的放射敏感性可能受某种遗传控制，这种遗传控制可能与HLA无关。
