Wadee A A, Rabson A R
Clin Exp Immunol. 1981 Aug;45(2):427-32.
Adherent cells from the spleen of guinea-pigs infected with Mycobacterium tuberculosis (M. tuberculosis) spontaneously released a factor which suppressed the blastogenic response of normal guinea-pig and human peripheral blood lymphocytes to PHA activation. Suppressor factor production was evident within 3 hr of culture, continued for 2 days and diminished thereafter. This effect was not observed in supernatants derived from normal guinea-pig splenic adherent cells or from peripheral blood adherent cells of both normal or M. tuberculosis-infected guinea-pigs. Analysis of the spontaneously generated adherent cell supernatant indicated that it activated a subpopulation of lymphocytes to become suppressor cells. We conclude that adherent cells phagocytosing M. tuberculosis at the site of the lesion release a factor which activates suppressor cells, and that these cells may be important in the cellular unresponsiveness which develops in animals or man with advanced tuberculosis.
感染结核分枝杆菌（M. tuberculosis）的豚鼠脾脏中的贴壁细胞自发释放一种因子，该因子可抑制正常豚鼠和人外周血淋巴细胞对PHA激活的增殖反应。培养3小时内即可明显产生抑制因子，持续2天，此后逐渐减少。在正常豚鼠脾贴壁细胞或正常或感染结核分枝杆菌的豚鼠外周血贴壁细胞的上清液中未观察到这种效应。对自发产生的贴壁细胞上清液的分析表明，它激活了淋巴细胞亚群使其成为抑制细胞。我们得出结论，在病变部位吞噬结核分枝杆菌的贴壁细胞释放一种激活抑制细胞的因子，并且这些细胞可能在患有晚期结核病的动物或人中发生的细胞无反应性中起重要作用。
