人类结核病的谱系
The spectrum of human tuberculosis.
作者信息
Lenzini L, Rottoli P, Rottoli L
出版信息
Clin Exp Immunol. 1977 Feb;27(2):230-7.
Abstract
Clinical, morphological and immunological studies of human tuberculosis have enabled the spectrum of the disease to be determined. We have investigated the cell-mediated immune responses by means of skin tests and leucocyte migration inhibition to PPD, and the humoral immune responses by means of immunodiffusion and haemagglutination tests. Patients with tuberculosis can be classified into two polar groups--reactive (RR) and unreactive (UU), the former showing good cell-mediated immunity and little or no antibody formation and the latter poor cellular responses and exuberant antibody production. The intermediate forms show characteristics of the neighbouring polar groups. The existence of a spectrum of immune response in tuberculosis, which has long been suspected, is now demonstrated.
摘要
对人类结核病的临床、形态学和免疫学研究已能够确定该疾病的范围。我们通过皮肤试验和对结核菌素纯蛋白衍生物（PPD）的白细胞游走抑制来研究细胞介导的免疫反应，并通过免疫扩散和血凝试验来研究体液免疫反应。结核病患者可分为两个极端组——反应性（RR）和无反应性（UU），前者表现出良好的细胞介导免疫力且很少或不产生抗体，而后者细胞反应较差但抗体产生旺盛。中间形式表现出相邻极端组的特征。长期以来一直被怀疑的结核病免疫反应范围的存在，现在得到了证实。
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