Arnaud-Battandier F, Nelson D L
Gastroenterology. 1982 Feb;82(2):248-53.
Populations of lymphoid cells from the gastrointestinal tract of guinea pigs were compared with splenic cells for both morphologic and functional characteristics. Gastrointestinal lymphoid cells were isolated from mesenteric lymph nodes, Peyer's patches, and also for the epithelium and lamina propria of the small intestinal mucosa. Isolated intraepithelial and lamina propria lymphocyte populations contained (a) T cells, B cells, and macrophages; (b) T cells that proliferated to phytohemagglutinin and concanavalin A; and (c) B cells that proliferated to bacterial lipopolysaccharide. Using inbred guinea pigs, the intraepithelial and lamina propria lymphocytes were shown to contain T cells capable of proliferating to alloantigens in mixed leukocyte culture, and also cells capable of stimulating alloreactive T cells. These studies demonstrate the presence of immunologically reactive T cells and B cells in isolated small intestinal mucosal lymphoid cells from guinea pigs.
对豚鼠胃肠道的淋巴细胞群与脾细胞的形态学和功能特征进行了比较。胃肠道淋巴细胞是从肠系膜淋巴结、派尔集合淋巴结以及小肠黏膜的上皮和固有层分离得到的。分离出的上皮内和固有层淋巴细胞群包含：（a）T细胞、B细胞和巨噬细胞；（b）对植物血凝素和刀豆球蛋白A有增殖反应的T细胞；（c）对细菌脂多糖有增殖反应的B细胞。利用近交系豚鼠，研究表明上皮内和固有层淋巴细胞含有在混合白细胞培养中能对同种异体抗原产生增殖反应的T细胞，以及能够刺激同种异体反应性T细胞的细胞。这些研究证明了从豚鼠分离出的小肠黏膜淋巴细胞中存在具有免疫反应性的T细胞和B细胞。
