影响头孢哌酮对脆弱拟杆菌群体外活性的因素。
Factors affecting the in vitro activity of cefoperazone against the Bacteroides fragilis group.
作者信息
Sutter V L, Kwok Y Y
出版信息
Antimicrob Agents Chemother. 1981 Dec;20(6):723-5. doi: 10.1128/AAC.20.6.723.
Abstract
The in vitro activity of cefoperazone against 32 strains of bacteria of the Bacteroides fragilis group was determined on four media by using a variety of test parameters. Lower mean minimal inhibitory concentrations (MICs) were obtained on Mueller-Hinton blood agar and supplemented brain heart infusion agar than were obtained on brucella laked blood agar or Wilkins-Chalgren agar. Higher MICs were obtained with 6-h inocula than with 24-h inocula, and slightly higher MICs were obtained with tests read at 48 as compared with 24 h. Conducting tests in an anaerobic glove box had little effect. The greatest differences in mean MICs were seen with inoculum densities of 10(4) and 10(5) colony-forming units.
摘要
采用多种测试参数，在四种培养基上测定了头孢哌酮对32株脆弱拟杆菌属细菌的体外活性。与布鲁氏菌溶血琼脂或威尔金斯-查尔格伦琼脂相比，在穆勒-欣顿血琼脂和补充脑心浸液琼脂上获得的平均最低抑菌浓度（MIC）更低。接种6小时时获得的MIC高于接种24小时时，且与24小时读数的测试相比，48小时读数的测试获得的MIC略高。在厌氧手套箱中进行测试影响不大。接种密度为10⁴和10⁵菌落形成单位时，平均MIC的差异最大。
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