Kaye D, Kobasa W, Kaye K
Antimicrob Agents Chemother. 1980 Jun;17(6):957-60. doi: 10.1128/AAC.17.6.957.
Two hundred fifty clinical isolates of anaerobic bacteria were tested for suceptibility to cefoperazone, cefamandole, cefoxitin, carbenicillin, clindamycin, and chloramphenicol. Anaerobic gram-positive cocci were susceptible to all of the antibiotics tested. Clindamycin was the most active agent against Bacteroides species, followed by chloramphenicol and then cefoxitin. Cefoperazone was less active than cefoxitin and equal in activity to carbenicillin. Cefamandole was the least active antibiotic against Bacteroides. B. distasonis, B. vulgatus, B. thetaiotaomicron, and B. ovatus were more resistant to the antibiotics than B. melaninogenicus, B. oralis, or B. bivius. Clindamycin was the most active agent against Clostridium species, followed by chloramphenicol; the three cephalosporins and carbenicillin were about equal in activity. Clindamycin was the most active antibiotic against Fusobacterium species, followed by chloramphenicol, carbenicillin, and cefoperazone (which were about equally active) and then cefamandole.
对250株厌氧菌临床分离株进行了头孢哌酮、头孢孟多、头孢西丁、羧苄西林、克林霉素和氯霉素的药敏试验。厌氧革兰氏阳性球菌对所有测试抗生素均敏感。克林霉素是对拟杆菌属最有效的药物，其次是氯霉素，然后是头孢西丁。头孢哌酮的活性低于头孢西丁，与羧苄西林活性相当。头孢孟多是对拟杆菌活性最低的抗生素。与产黑素拟杆菌、口腔拟杆菌或双叉拟杆菌相比，狄氏拟杆菌、普通拟杆菌、多形拟杆菌和卵形拟杆菌对这些抗生素的耐药性更强。克林霉素是对梭菌属最有效的药物，其次是氯霉素；三种头孢菌素和羧苄西林的活性大致相当。克林霉素是对梭杆菌属最有效的抗生素，其次是氯霉素、羧苄西林和头孢哌酮（活性大致相同），然后是头孢孟多。
