Ricoy J R, Ortega A, Cabello A
J Neurol Sci. 1982 Feb;53(2):241-51. doi: 10.1016/0022-510x(82)90010-7.
A 72-year-old Caucasian woman developed degeneration of the spinal cord long tracts, polyneuropathy, and optic atrophy after chronic ingestion of clioquinol (200 mg/day) since she was 45. Diseases with a similar clinical picture, notably vitamin B12 deficiency (B12D), and subacute myelo-optic neuropathy (SMON), are discussed with regard to the pathologic findings. In our patient findings were different from those reported in B12D, but similar to those in SMON. If, as we believe, our patient was suffering from the same disease as the SMON described by Japanese authors, this is the first case reported outside Japan in which pathological verification has been obtained.
一名72岁的白种女性，自45岁起长期服用氯碘喹啉（每日200毫克）后，出现脊髓长束变性、多发性神经病和视神经萎缩。文中结合病理检查结果，讨论了具有相似临床表现的疾病，特别是维生素B12缺乏症（B12D）和亚急性脊髓视神经病变（SMON）。我们的患者的检查结果与B12D报道的不同，但与SMON的相似。如果我们的患者所患疾病与日本作者描述的SMON相同（我们也这样认为），那么这是日本境外报道的首例获得病理证实的病例。
