Anttinen H, Järvensivu P M, Savolainen E R
Eur J Clin Invest. 1981 Oct;11(5):375-9. doi: 10.1111/j.1365-2362.1981.tb01999.x.
Changes in serum galactosylhydroxylysyl glucosyltransferase, an enzyme catalysing one of the intracellular post-translational modifications in collagen biosynthesis, were studied in twenty-four patients with acute myocardial infarction. The enzyme activity was monitored for 18 days from the onset of infarction, and at least a two-peaked pattern was observed. The first peak corresponded to the stage of acute myocardial injury, there being a highly significant correlation between the maximal values for serum glucosyltransferase and alpha-hydroxybutyrate dehydrogenase. An average decreasing in serum glucosyltransferase activity of 41%, was noted during the following 24 h. A new gradual rise in serum glucosyltransferase activity, interpreted as indicating myocardial collagen scar formation, was observed 5 days after the onset of infarction, when the serum enzyme activities indicating myocardial injury had already declined. The average daily values for serum glucosyltransferase between 6 and 18 days correlated highly significantly with the maximal value for serum alpha-hydroxybutyrate dehydrogenase, which serves as a relative estimate of the size of the original myocardial infarction area. The data further suggest that certain other factors including heart failure and/or various drug treatments may also affect the magnitude of this second peak.
对24例急性心肌梗死患者体内血清半乳糖基羟赖氨酰葡糖基转移酶（一种催化胶原蛋白生物合成中细胞内翻译后修饰反应之一的酶）的变化进行了研究。从梗死发作开始对该酶活性监测18天，至少观察到一种双峰模式。第一个峰值对应急性心肌损伤阶段，血清葡糖基转移酶的最大值与α-羟丁酸脱氢酶之间存在高度显著的相关性。在接下来的24小时内，血清葡糖基转移酶活性平均下降了41%。梗死发作5天后，观察到血清葡糖基转移酶活性出现新的逐渐上升，这被解释为表明心肌胶原瘢痕形成，此时表明心肌损伤的血清酶活性已经下降。梗死发作6至18天期间血清葡糖基转移酶的日均数值与血清α-羟丁酸脱氢酶的最大值高度显著相关，α-羟丁酸脱氢酶可作为对原始心肌梗死面积大小的相对估计。数据进一步表明，包括心力衰竭和/或各种药物治疗在内的某些其他因素也可能影响这第二个峰值的大小。
