下丘脑-免疫相互作用。I. 下丘脑前部损伤对免疫反应的急性影响。
Hypothalamic-immune interactions. I. The acute effect of anterior hypothalamic lesions on the immune response.
作者信息
Cross R J, Markesbery W R, Brooks W H, Roszman T L
出版信息
Brain Res. 1980 Aug 25;196(1):79-87. doi: 10.1016/0006-8993(80)90717-9.
PMID:7397532
Abstract
Rats with electrolytic anterior hypothalamic lesions show changes in lymphoid tissue cellularity and a decrease in the response to concanavalin A (Con A). This effect manifests itself maximally 4 days after lesioning, with a return to normal by day 14. The changes are not mediated through the release of corticosteroids. These data indicate the presence of a neuroendocrine pathway that is capable of modulating immune function.
摘要
患有下丘脑前部电解损伤的大鼠，其淋巴组织细胞数量出现变化，对伴刀豆球蛋白A（Con A）的反应降低。这种效应在损伤后4天表现得最为明显，到第14天恢复正常。这些变化并非通过皮质类固醇的释放介导。这些数据表明存在一条能够调节免疫功能的神经内分泌途径。
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