HLA - B与较罕见的备解素因子B等位基因BfF1和BfS1之间的连锁不平衡。

Linkage disequilibria between HLA-B and the rarer properdin factor B alleles, BfF1 and BfS1.

作者信息

Stewart G J, Cann H M, Grumet F C, Hay J, Kirk R L, Payne R

出版信息

Hum Immunol. 1980 Jul;1(1):31-6. doi: 10.1016/0198-8859(80)90007-5.

Abstract

Phenotypic association and highly significant linkage disequilibria have been demonstrated for HLA-B18 and BfF1 and HLA-Bw50 and BfS1 alleles among Caucasians from Australia and the United States (San Francisco Bay area). The HLA-B18, BfF1 association appears to be associated with HLA-Aw30. It is possible that BfS1 arose as a mutation, after the evolutionary splitting of HLA-Bw21, on an HLA-Bw50 haplotype, and that BfF1 arose on an HLA-Aw30, B18 haplotype.

摘要

在来自澳大利亚和美国（旧金山湾区）的白种人中，已证实HLA - B18与BfF1以及HLA - Bw50与BfS1等位基因之间存在表型关联和高度显著的连锁不平衡。HLA - B18与BfF1的关联似乎与HLA - Aw30有关。有可能BfS1是在HLA - Bw21进化分裂后，在一个HLA - Bw50单倍型上作为突变产生的，而BfF1是在一个HLA - Aw30、B18单倍型上产生的。