儿童庆大霉素的剂量。
Gentamicin dosage in children.
作者信息
Taylor M, Keane C
出版信息
Arch Dis Child. 1976 May;51(5):369-72. doi: 10.1136/adc.51.5.369.
Abstract
The results of 49 serum gentamicin assays from children of 2 weeks to 11 years of age are presented. The dose of gentamicin given 8-hourly intramuscularly ranged from 0-7 mg/kg-4-9 mg/kg. Doses of 1-7 mg/kg or less did not give adequate serum concentrations. As a result of these observations it is suggested that an intramuscular dose of 2-5 mg/kg given 8-hourly is suitable for most children in the absence of renal failure, but that adjustment of the dose according to serum gentamicin concentration is necessary.
摘要
本文呈现了2周龄至11岁儿童49次血清庆大霉素检测结果。每8小时肌肉注射一次的庆大霉素剂量范围为0 - 7mg/kg至4 - 9mg/kg。1 - 7mg/kg或更低剂量无法产生足够的血清浓度。基于这些观察结果，建议在无肾衰竭情况下，大多数儿童每8小时肌肉注射2 - 5mg/kg的剂量是合适的，但根据血清庆大霉素浓度调整剂量是必要的。
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本文引用的文献
1
Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.
J Infect Dis. 1971 Dec;124 Suppl:S130-7. doi: 10.1093/infdis/124.supplement_1.s130.
2
The current status of gentamicin for tne neonate and young infant.
Am J Dis Child. 1972 Jul;124(1):13-4. doi: 10.1001/archpedi.1972.02110130015002.
3
Clinical and laboratory evaluation of gentamicin in infants and children.
J Infect Dis. 1971 Dec;124 Suppl:S236-46. doi: 10.1093/infdis/124.supplement_1.s236.
4
Pseudomonas bacteremia: pharmacologic and other bases for failure of treatment with gentamicin.
J Infect Dis. 1971 Dec;124 Suppl:S185-91. doi: 10.1093/infdis/124.supplement_1.s185.
5
Gentamicin in pediatrics. II. Treatment of severe urinary-tract infections caused by gram-negative bacilli and of staphylococcal infections.
J Infect Dis. 1971 Dec;124 Suppl:S257-63. doi: 10.1093/infdis/124.supplement_1.s257.
6
Gentamicin in newborn infants. Comparison of intramuscular and intravenous administration.
Am J Dis Child. 1973 Oct;126(4):473-7. doi: 10.1001/archpedi.1973.02110190393006.
7
Gentamicin in paediatrics.
Postgrad Med J. 1974 Nov;50 Suppl 7:45-52.
8
Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis.
Br Med J. 1974 Mar 16;1(5906):477-81. doi: 10.1136/bmj.1.5906.477.
9
Letter: Serum levels of gentamicin after intravenous bolus injection.
Lancet. 1974 Apr 20;1(7860):730. doi: 10.1016/s0140-6736(74)92929-8.
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