Taylor M, Keane C
Arch Dis Child. 1976 May;51(5):369-72. doi: 10.1136/adc.51.5.369.
The results of 49 serum gentamicin assays from children of 2 weeks to 11 years of age are presented. The dose of gentamicin given 8-hourly intramuscularly ranged from 0-7 mg/kg-4-9 mg/kg. Doses of 1-7 mg/kg or less did not give adequate serum concentrations. As a result of these observations it is suggested that an intramuscular dose of 2-5 mg/kg given 8-hourly is suitable for most children in the absence of renal failure, but that adjustment of the dose according to serum gentamicin concentration is necessary.
本文呈现了2周龄至11岁儿童49次血清庆大霉素检测结果。每8小时肌肉注射一次的庆大霉素剂量范围为0 - 7mg/kg至4 - 9mg/kg。1 - 7mg/kg或更低剂量无法产生足够的血清浓度。基于这些观察结果，建议在无肾衰竭情况下，大多数儿童每8小时肌肉注射2 - 5mg/kg的剂量是合适的，但根据血清庆大霉素浓度调整剂量是必要的。
