Martin N D, Snodgrass G J, Cohen R D
Arch Dis Child. 1984 Jul;59(7):605-13. doi: 10.1136/adc.59.7.605.
Seventy six children with documented Fanconi-type idiopathic infantile hypercalcaemia were studied and compared with 41 with the Williams-Beuren syndrome. Clinical comparison showed, as expected, very close similarities but also considerable differences, particularly in the severity of feeding problems and the degree of failure to thrive. The estimated incidence of idiopathic infantile hypercalcaemia alone has remained constant for the past 20 years, at approximately 18 cases per year in the United Kingdom (1 per 47 000 total live births). Long term morbidity in these children is mainly due to mental handicap and arteriopathy, but hypertension (29%), kyphoscoliosis (19%), hyperacusis (75%), and obesity (50%) may be added complications. In one child, hypercalcaemia recurred during adolescence but this seems to be excessively rare. More detailed investigation before treatment is required to discover the aetiology of hypercalcaemia in this condition.
对76例有记录的范可尼型特发性婴儿高钙血症患儿进行了研究，并与41例威廉姆斯-贝伦综合征患儿进行了比较。临床比较显示，正如预期的那样，两者有非常密切的相似之处，但也有相当大的差异，特别是在喂养问题的严重程度和生长发育迟缓的程度方面。仅特发性婴儿高钙血症的估计发病率在过去20年中一直保持不变，在英国每年约有18例（每47000例总活产中有1例）。这些儿童的长期发病主要是由于智力障碍和动脉病变，但高血压（29%）、脊柱后凸（19%）、听觉过敏（75%）和肥胖（50%）可能是附加的并发症。在一名儿童中，高钙血症在青春期复发，但这似乎极为罕见。在治疗前需要进行更详细的调查，以发现这种情况下高钙血症的病因。
