治疗性输注后所发现的血浆浓度下阿霉素对粒-巨噬细胞集落形成单位的影响。
Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
作者信息
Bailey-Wood R, Dallimore C M, Whittaker J A
出版信息
Br J Cancer. 1984 Sep;50(3):351-5. doi: 10.1038/bjc.1984.182.
Abstract
The effect of adriamycin on human and mouse CFUGM was examined at concentrations and times suggested by plasma clearance data derived from the results of a number of published studies. Our results suggest that the high concentrations of drug present in the plasma for short periods of time following infusion are only weakly cytotoxic towards the CFUGM when incubated for similar times. In contrast, there was a considerably greater cytotoxic effect when the drug was examined at low concentrations for periods similar to those described for the terminal phase of adriamycin clearance. The principal metabolite, adriamycinol, was poorly cytotoxic.
摘要
根据多项已发表研究结果得出的血浆清除数据所建议的浓度和时间，检测了阿霉素对人及小鼠粒-巨噬细胞集落形成单位（CFUGM）的影响。我们的结果表明，输注后短时间内血浆中存在的高浓度药物，在类似时间孵育时，对CFUGM的细胞毒性较弱。相比之下，当以低浓度检测药物并在与阿霉素清除末期相似的时间段内进行观察时，细胞毒性作用要大得多。主要代谢产物阿霉素醇的细胞毒性较弱。
相似文献
1
Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.治疗性输注后所发现的血浆浓度下阿霉素对粒-巨噬细胞集落形成单位的影响。
Br J Cancer. 1984 Sep;50(3):351-5. doi: 10.1038/bjc.1984.182.
2
Determination of adriamycin, adriamycinol and their 7-deoxyaglycones in human serum by high-performance liquid chromatography.高效液相色谱法测定人血清中的阿霉素、阿霉素醇及其7-脱氧糖苷配基
J Chromatogr. 1984 Nov 9;311(1):125-33. doi: 10.1016/s0378-4347(00)84698-8.
3
4
Characterization of canine fetal lymphohematopoiesis: studies of CFUGM, CFUL, and CFUF.
Exp Hematol. 1983 Apr;11(4):263-74.
5
Determination of adriamycin and its fluorescent metabolites in human plasma by HPLC.采用高效液相色谱法测定人血浆中阿霉素及其荧光代谢产物。
Biomed Chromatogr. 1987 Feb;2(1):38-40. doi: 10.1002/bmc.1130020111.
6
Cryopreservation of the human multipotent stem cell.人类多能干细胞的低温保存
Exp Hematol. 1982 Jan;10(1):119-22.
7
Toxicity of doxorubicin metabolites to human marrow erythroid and myeloid progenitors in vitro.阿霉素代谢产物对人骨髓红系和髓系祖细胞的体外毒性。
Cancer Treat Rep. 1986 Apr;70(4):487-90.
8
[Stem cell factor (SCF) supports granulocyte progenitor survival in mouse bone marrow cultures].[干细胞因子（SCF）在小鼠骨髓培养物中支持粒细胞祖细胞存活]
Rev Invest Clin. 1999 Mar-Apr;51(2):107-16.
9
Culture of colony forming cells of macrophages and granulocytes from mouse bone marrow.
Arch Invest Med (Mex). 1983;14(1):15-21 passim.
10
Inhibition of human ovarian cancer colony formation by adriamycin and its major metabolites.
Cancer Res. 1980 Nov;40(11):4109-12.
引用本文的文献
1
The effect of etoposide on human CFU-GM.依托泊苷对人粒-巨噬细胞集落形成单位的作用。
Br J Cancer. 1985 Oct;52(4):613-7. doi: 10.1038/bjc.1985.234.
2
Infusion-rate independent cellular adriamycin concentrations and cytotoxicity to human bone marrow clonogenic cells (CFU-GM).输注速率无关的阿霉素细胞浓度及对人骨髓克隆形成细胞（CFU-GM）的细胞毒性。
Br J Cancer. 1987 Aug;56(2):123-6. doi: 10.1038/bjc.1987.168.
3
A pharmacokinetic study of adriamycin and 4'epi-adriamycin after simultaneous intra-arterial liver administration.
Med Oncol Tumor Pharmacother. 1986;3(2):105-10. doi: 10.1007/BF02934562.
4
Intracellular concentrations of anti cancer drugs in leukemic cells in vitro vs in vivo.
Cancer Chemother Pharmacol. 1990;25(4):252-6. doi: 10.1007/BF00684881.
本文引用的文献
1
Inhibition of human ovarian cancer colony formation by adriamycin and its major metabolites.
Cancer Res. 1980 Nov;40(11):4109-12.
2
[The pharmacokinetics of adriamycin and adriamycin-metabolites (author's transl)].阿霉素及阿霉素代谢产物的药代动力学（作者译）
Klin Wochenschr. 1980 Sep 15;58(18):927-34. doi: 10.1007/BF01477050.
3
Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion.通过延长持续静脉输注降低阿霉素的心脏毒性。
Ann Intern Med. 1982 Feb;96(2):133-9. doi: 10.7326/0003-4819-96-2-133.
4
Pharmacokinetics of adriamycin in patients with breast cancer: correlation between pharmacokinetic parameters and clinical short-term response.
Eur J Cancer Clin Oncol. 1982 Aug;18(8):739-45. doi: 10.1016/0277-5379(82)90072-4.
5
Age dependence of the early-phase pharmacokinetics of doxorubicin.多柔比星早期药代动力学的年龄依赖性
Cancer Res. 1983 Sep;43(9):4467-9.
6
Plasma and urinary levels of adriamycin in man.人体内阿霉素的血浆和尿液水平。
Eur J Cancer (1965). 1972 Aug;8(4):455-9. doi: 10.1016/0014-2964(72)90132-6.
7
Clinical effects and pharmacokinetics of different dosage schedules of adriamycin.阿霉素不同给药方案的临床疗效及药代动力学
Cancer Res. 1976 Jan;36(1):216-21.
8
Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function.阿霉素及其代谢产物在肝肾功能正常的人体中的血浆药代动力学。
Cancer Res. 1977 May;37(5):1416-20.
9
Prediction of adriamycin disposition in cancer patients using a physiologic, pharmacokinetic model.
Cancer Treat Rep. 1978 Aug;62(8):1161-71.
10
Stimulation of in vitro granulocyte--macrophage colony formation by mouse heart conditioned medium.
Br J Haematol. 1978 Oct;40(2):197-204. doi: 10.1111/j.1365-2141.1978.tb03657.x.
Zotero 插件