Luchakov Iu I, Kisliakov Iu Ia
Biofizika. 1984 May-Jun;29(3):442-6.
Distribution dynamics of oxygen tension throughout the erythrocyte volume was calculated by means of a mathematical model describing the dynamics of oxygen transport in the erythrocyte, its shape, diffusion resistance of hemoglobin solution. The pattern of the dissociation curve of oxyhemoglobin being taken into account. The model is presented as a system of differential equations in partial derivatives. Its solution was performed on an electron computer by a net method. Sharp jumps of pO2 inside the erythrocyte at its fast movements in the media with different partial pressure of O2 were shown. A quantitative relationship was found between the rate of physico-chemical reactions of oxygen binding and yield by hemoglobin and the level of hemoglobin saturation with oxygen.
通过一个描述红细胞内氧气运输动力学、其形状、血红蛋白溶液扩散阻力的数学模型，计算了整个红细胞体积内氧分压的分布动态。同时考虑了氧合血红蛋白解离曲线的模式。该模型以偏微分方程组的形式呈现。其解是通过电子计算机用网络方法进行的。结果表明，当红细胞在不同氧分压的介质中快速移动时，其内部的pO₂会出现急剧跳跃。发现了氧气与血红蛋白结合和释放的物理化学反应速率与血红蛋白氧饱和度水平之间的定量关系。
