Sudakov S K, Ivetich V
Biull Eksp Biol Med. 1984 Jul;98(7):5-6.
Single unit activity of the rabbit dorsal hippocamp in response to electric stimulation of the food centers of the lateral hypothalamus has been studied. Threshold stimulation produced food motivation and subthreshold one the orienting-research reactions. Microiontophoretic application to the neurons of the protein synthesis blocker cycloheximide induced changes in single unit activity in response to threshold stimulation in 79% of cases, whereas to subthreshold stimulation in 53% of cases. Application to these neurons of pentagastrin recovered the reactions only to threshold stimulation. It is inferred that the involvement of the majority of CA3 dorsal hippocampal neurons in food motivation requires the presence in the perineuronal space of a definite amount of pentagastrin that is likely to be synthesized, under normal conditions during motivational stimulation, in the given or adjacent neurons.
对家兔背侧海马在受到下丘脑外侧食物中枢电刺激时的单单位活动进行了研究。阈下刺激产生食物动机，阈刺激产生定向探究反应。向神经元微量离子电泳施加蛋白质合成阻滞剂环己酰亚胺，在79%的情况下会引起对阈刺激的单单位活动变化，而在53%的情况下会引起对阈下刺激的单单位活动变化。向这些神经元施加五肽胃泌素仅恢复了对阈刺激的反应。据推测，背侧海马CA3区的大多数神经元参与食物动机需要在神经元周围间隙中存在一定量的五肽胃泌素，在正常情况下，在动机刺激期间，这些五肽胃泌素可能是在给定或相邻神经元中合成的。
