Ginsburg R, Bristow M R, Davis K
Circ Res. 1984 Sep;55(3):416-21. doi: 10.1161/01.res.55.3.416.
We studied isolated ring segments from a number of sites along the course of epicardial coronary arteries from 24 human hearts in order to characterize regional responsiveness to vasoactive agents. Concentration-response curves revealed heightened sensitivity to histamine in the proximal portion of the coronary arteries, and increased sensitivity to carbachol in the distal portion of these same vessels. In contrast, the response to stimulation by calcium or phenylephrine was uniform throughout the length of the vessels examined. These data suggest that regional variations in agonist response reflect heterogeneity in receptor populations along the course of the human epicardial coronary artery.
我们研究了取自24颗人类心脏的心外膜冠状动脉沿途多个部位的孤立环形节段，以表征对血管活性药物的局部反应性。浓度-反应曲线显示，冠状动脉近端对组胺的敏感性增强，而在这些相同血管的远端对卡巴胆碱的敏感性增加。相比之下，在所检查血管的整个长度上，对钙或去氧肾上腺素刺激的反应是一致的。这些数据表明，激动剂反应的局部差异反映了人类心外膜冠状动脉沿途受体群体的异质性。
