基于甲基的产甲烷作用：生态与基因组学综述。
Methyl-Based Methanogenesis: an Ecological and Genomic Review.
机构信息
Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
出版信息
Microbiol Mol Biol Rev. 2023 Mar 21;87(1):e0002422. doi: 10.1128/mmbr.00024-22. Epub 2023 Jan 24.
Methyl-based methanogenesis is one of three broad categories of archaeal anaerobic methanogenesis, including both the methyl dismutation (methylotrophic) pathway and the methyl-reducing (also known as hydrogen-dependent methylotrophic) pathway. Methyl-based methanogenesis is increasingly recognized as an important source of methane in a variety of environments. Here, we provide an overview of methyl-based methanogenesis research, including the conditions under which methyl-based methanogenesis can be a dominant source of methane emissions, experimental methods for distinguishing different pathways of methane production, molecular details of the biochemical pathways involved, and the genes and organisms involved in these processes. We also identify the current gaps in knowledge and present a genomic and metagenomic survey of methyl-based methanogenesis genes, highlighting the diversity of methyl-based methanogens at multiple taxonomic levels and the widespread distribution of known methyl-based methanogenesis genes and families across different environments.
基于甲基的产甲烷作用是古菌厌氧产甲烷作用的三大类之一，包括甲基歧化（甲基营养型）途径和甲基还原（也称为氢依赖型甲基营养型）途径。基于甲基的产甲烷作用正日益被认为是各种环境中甲烷的重要来源。在这里，我们概述了基于甲基的产甲烷作用的研究，包括在何种条件下基于甲基的产甲烷作用可以成为甲烷排放的主要来源、区分不同甲烷产生途径的实验方法、涉及的生化途径的分子细节，以及这些过程中涉及的基因和生物体。我们还确定了当前知识的差距，并对基于甲基的产甲烷作用基因进行了基因组和宏基因组调查，突出了在多个分类学水平上基于甲基的产甲烷生物的多样性，以及已知的基于甲基的产甲烷作用基因和家族在不同环境中的广泛分布。
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