原位杂交与易位断点定位。I. 慢性粒细胞白血病的t(9;22)和伯基特淋巴瘤的t(8;22)的22q11非同源断点
In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma.
作者信息
Emanuel B S, Selden J R, Wang E, Nowell P C, Croce C M
出版信息
Cytogenet Cell Genet. 1984;38(2):127-31. doi: 10.1159/000132044.
PMID:6467987
Abstract
In situ chromosomal hybridization of a probe for part of the lambda light chain constant region (C lambda) has demonstrated that the 22q11 breakpoints of chronic myelogenous leukemia (CML) t(9;22) and Burkitt lymphoma t(8;22) are not identical. For CML, the breakpoint is distal to the IGLC genes, whereas for Burkitt lymphoma it is proximal. The study provides direct evidence for regional assignment of the IGLC gene cluster to 22q11.
摘要
针对λ轻链恒定区（Cλ）部分的探针进行的原位染色体杂交表明，慢性粒细胞白血病（CML）t(9;22)和伯基特淋巴瘤t(8;22)的22q11断点并不相同。对于CML，断点位于IGLC基因的远端，而对于伯基特淋巴瘤，断点位于近端。该研究为将IGLC基因簇定位到22q11提供了直接证据。
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