Konishi F, Muto T, Kamiya J, Sawada T, Sugihara K, Morioka Y, Morson B C, Bussey H J
Dis Colon Rectum. 1984 Aug;27(8):515-8. doi: 10.1007/BF02555509.
Histopathologic comparison of colorectal adenomas removed at St. Mark's Hospital, London, England, and those removed at the University of Tokyo, Japan was performed. There were 1242 lesions in the St. Mark's series and 310 in the University of Tokyo series. All adenomas were removed either by colonoscopic polypectomy or hot biopsy. The indications and methods of colonoscopic removal were similar in the two series. Age distribution of the patients showed a younger peak incidence in the University of Tokyo series compared with the St. Mark's patients. The percentage of adenomas larger than 1 cm, of tubulovillous or villous type, and with moderate or severe dysplasia were greater in the St. Mark's series than in the University of Tokyo series. Percentages of adenomas with mild, moderate, or severe dysplasia in each category of size did not differ between the two series. In view of the fact that there is a high colorectal cancer risk in England and medium cancer risk in Japan, our results give further epidemiologic support to the concept of the adenoma-carcinoma sequence.
对在英国伦敦圣马克医院切除的大肠腺瘤与在日本东京大学切除的大肠腺瘤进行了组织病理学比较。圣马克医院系列有1242个病变，东京大学系列有310个病变。所有腺瘤均通过结肠镜息肉切除术或热活检切除。两个系列中结肠镜切除的适应证和方法相似。与圣马克医院的患者相比，东京大学系列患者的年龄分布显示出更年轻的发病高峰。圣马克医院系列中直径大于1 cm、呈管状绒毛状或绒毛状类型且有中度或重度发育异常的腺瘤百分比高于东京大学系列。两个系列中各大小类别中轻度、中度或重度发育异常腺瘤的百分比无差异。鉴于英国结直肠癌风险高而日本为中度癌症风险，我们的结果为腺瘤-癌序列概念提供了进一步的流行病学支持。
