Baird-Lambert J, Doyle P E, Thomas D, Jager-Roman E, Cvejic M, Buchanan N
Dev Pharmacol Ther. 1984;7(4):239-44. doi: 10.1159/000457170.
The effects of prenatal steroids on theophylline metabolism in infants of 27-32 weeks gestation was studied. Although in utero exposure to betamethasone was associated with a more mature theophylline metabolite pattern in the first days of life, initial elimination half-life (t1/2 beta) did not differ significantly between groups. By the second or third week of life the metabolite pattern was similar in all infants. The decline in t1/2 beta seen during theophylline treatment was not directly related to increased metabolite formation. These data suggest that other factors, such as renal clearance, are more important in determining the pharmacokinetics of theophylline in neonates than is hepatic metabolism.
研究了产前使用类固醇对妊娠27 - 32周婴儿茶碱代谢的影响。尽管子宫内暴露于倍他米松与出生后最初几天更成熟的茶碱代谢物模式有关，但两组之间的初始消除半衰期（t1/2β）没有显著差异。到出生后第二或第三周，所有婴儿的代谢物模式相似。茶碱治疗期间观察到的t1/2β下降与代谢物形成增加没有直接关系。这些数据表明，在决定新生儿茶碱的药代动力学方面，其他因素，如肾脏清除率，比肝脏代谢更重要。
