Thiault G A, Le Guen Y, Boucherle A, Walrant P
Farmaco Sci. 1984 Jun;39(6):524-37.
The derivatives in question are prepared by reaction of substituted anilines with 1,4-ketones in an acidic medium. The diketones are themselves obtained either using Friedel and Crafts reaction with levulinic acid chloride, or by Stetter's method reacting Mannich bases with aryl aldehydes in the presence of sodium cyanide. The results of test of acute toxicity and of analgesic and anti-inflammatory activity are reported.
所述衍生物是通过取代苯胺与1,4 - 二酮在酸性介质中反应制备的。二酮本身可通过与乙酰丙酸氯进行傅克反应获得，或者通过施泰特方法，在氰化钠存在下使曼尼希碱与芳基醛反应得到。报告了急性毒性以及镇痛和抗炎活性的测试结果。
