Maddern G J, Horowitz M, Jamieson G G, Chatterton B E, Collins P J, Roberts-Thomson P
Gastroenterology. 1984 Oct;87(4):922-6.
Gastric and esophageal emptying were assessed using scintigraphic techniques in 12 patients with progressive systemic sclerosis and 22 normal volunteers. Esophageal emptying was significantly delayed in the patient group, with 7 of the 12 patients beyond the normal range. Gastric emptying was slower in patients than in controls, with 9 patients being outside the normal range for solid emptying and 7 patients outside the normal range for liquid emptying. Findings from gastric and esophageal emptying tests generally correlated well with symptoms of dysphagia and gastroesophageal reflux. However, 2 patients with normal emptying studies had symptomatic heartburn, and 2 patients with delay of both solid and liquid gastric emptying gave no history of gastroesophageal reflux. Delayed gastric emptying may be an important factor in the development of upper gastrointestinal symptoms in patients with progressive systemic sclerosis.
采用闪烁扫描技术对12例进行性系统性硬化症患者和22名正常志愿者的胃和食管排空情况进行了评估。患者组食管排空明显延迟，12例患者中有7例超出正常范围。患者的胃排空比对照组慢，9例患者固体排空超出正常范围，7例患者液体排空超出正常范围。胃和食管排空试验结果一般与吞咽困难和胃食管反流症状密切相关。然而，2例排空研究正常的患者有烧心症状，2例固体和液体胃排空均延迟的患者无胃食管反流病史。胃排空延迟可能是进行性系统性硬化症患者上消化道症状发生的一个重要因素。
