Horowitz M, Maddox A F, Wishart J M, Harding P E, Chatterton B E, Shearman D J
Department of Medicine, Royal Adelaide Hospital, South Australia, Australia.
Eur J Nucl Med. 1991;18(4):229-34. doi: 10.1007/BF00186645.
In 87 randomly selected diabetic patients (67 type 1, 20 type 2) and 25 control subjects, gastric emptying of digestible solid and liquid meals and oesophageal transit of a solid bolus were measured with scintigraphic techniques. Gastrointestinal symptoms, autonomic nerve function and glycaemic control were evaluated in the diabetic patients. Gastric emptying and oesophageal transit were slower (P less than 0.001) in the diabetic patients compared with the control subjects, and each was delayed in about 40% of them. There was a relatively weak (r = 0.32; P less than 0.01) relationship between solid and liquid gastric emptying, and no significant correlation (r = 0.11, NS) between oesophageal transit and gastric emptying of the solid meal. Scores for upper gastrointestinal symptoms and autonomic nerve function correlated weakly (r = 0.21; P less than 0.05) with both oesophageal transit and gastric emptying. Gastric emptying of the liquid meal was slower (P less than 0.05) in patients with blood glucose concentrations greater than 15 mmol/l. These results indicate that gastric emptying in patients with diabetes mellitus should be assessed by liquid as well as by solid test meals and that oesophageal transit should not be used as a predictor of generalised diabetic gastroenteropathy.
在87例随机选取的糖尿病患者（1型67例，2型20例）和25名对照者中，采用闪烁扫描技术测量了可消化固体和液体餐的胃排空以及固体食团的食管转运。对糖尿病患者的胃肠道症状、自主神经功能和血糖控制情况进行了评估。与对照者相比，糖尿病患者的胃排空和食管转运较慢（P<0.001），约40%的患者存在延迟。固体和液体胃排空之间的关系相对较弱（r=0.32；P<0.01），食管转运与固体餐胃排空之间无显著相关性（r=0.11，无统计学意义）。上消化道症状评分和自主神经功能评分与食管转运和胃排空均呈弱相关（r=0.21；P<0.05）。血糖浓度大于15 mmol/l的患者液体餐胃排空较慢（P<0.05）。这些结果表明，糖尿病患者的胃排空应通过液体餐和固体餐试验进行评估，且食管转运不应作为全身性糖尿病胃肠病的预测指标。
