Duncan B M, Lloyd J V
Br J Haematol. 1978 Apr;38(4):551-60. doi: 10.1111/j.1365-2141.1978.tb01080.x.
Human brain is a common source of thromboplastin for the prothrombin time, where the end point is the conversion of fibrinogen to fibrin. Experiments showed that human brain also contains a proteolipid which inhibits the conversion of fibrinogen to fibrin. The proteolipid is removed when brain tissue is washed with acetone, but remains as a contaminant when brain is extracted with saline. For this reason prothrombin times on the same plasma are longer when saline extracts, rather than acetone dried preparations, are the source of thromboplastin. The proteolipid explains why the prothrombin time becomes shorter when saline extracts are diluted to standardize their activity against the British comparative thromboplastin.
人脑是凝血酶原时间检测中凝血活酶的常见来源，该检测的终点是纤维蛋白原转化为纤维蛋白。实验表明，人脑还含有一种蛋白脂质，它会抑制纤维蛋白原转化为纤维蛋白。用丙酮洗涤脑组织时，该蛋白脂质会被去除，但用盐水提取脑组织时，它会作为污染物残留下来。因此，当以盐水提取物而非丙酮干燥制剂作为凝血活酶来源时，同一血浆的凝血酶原时间会更长。这种蛋白脂质解释了为什么将盐水提取物稀释以使其活性与英国比较凝血活酶标准化时，凝血酶原时间会变短。
