Toy J L, Davies J A, Hancock K W, McNicol G P
Br J Obstet Gynaecol. 1978 May;85(5):359-62. doi: 10.1111/j.1471-0528.1978.tb14894.x.
A synthetic and a natural oestrogen were administered alternately for three months to nine women with primary amenorrhoea using a randomized cross-over schedule. Measurements of haemostatic function were performed before and at the end of each treatment period. No significant change in haemostatic function was observed after treatment with the 'natural' oestrogen, oestriol succinate. In contrast, treatment with a synthetic oestrogen, ethinyloestradiol, caused shortening of the prothrombin time and an increase in plasma concentration of factor VII and plasminogen. These data support other observations in suggesting that natural oestrogens may have fewer potentially adverse effects on haemostatic function than synthetic oestrogen.
采用随机交叉方案，对9名原发性闭经女性交替给予合成雌激素和天然雌激素，为期3个月。在每个治疗期开始前和结束时进行止血功能测量。使用天然雌激素琥珀酸雌三醇治疗后，未观察到止血功能有显著变化。相比之下，使用合成雌激素炔雌醇治疗会导致凝血酶原时间缩短，以及因子VII和纤溶酶原的血浆浓度增加。这些数据支持了其他观察结果，表明天然雌激素对止血功能的潜在不良影响可能比合成雌激素少。
