Davies T, Fieldhouse G, McNicol G P
Thromb Haemost. 1976 Apr 30;35(2):403-14.
The effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 mug/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.
为预防绝经后女性骨质流失而给予雌激素治疗对止血机制的影响已得到研究。对10名女性口服琥珀酸雌三醇，剂量为每日2毫克，持续1个月，之后每月递增2毫克，再持续3个月。10名女性中有6名随后接受每日25微克口服炔雌醇的治疗。琥珀酸雌三醇治疗导致因子VII水平略有升高、因子VIII浓度降低以及血小板对聚集剂的敏感性增加。炔雌醇治疗导致更广泛的变化，凝血因子VII、VIII、IX和X显著增加，抗凝血酶水平降低，循环纤溶酶原水平和优球蛋白溶解活性急剧增加。数据表明，治疗中使用的雌激素的性质对于确定雌激素治疗对止血机制成分的定性和定量影响很重要。
