Toy J L, Davies J A, McNicol G P
Br J Obstet Gynaecol. 1978 May;85(5):363-6. doi: 10.1111/j.1471-0528.1978.tb14895.x.
In a previous report we showed that oestriol succinate administered to postmenopausal women caused fewer changes in haemostatic function over a four-month period than ethinyloestradiol. Potential longer-term effects were studied in postmenopausal women treated for osteoporosis with oestriol succinate for up to 12 months. Over this period there was no significant change in concentration of plasma coagulation factors, an increase in plasminogen concentration and euglobulin lysis activity, and an inconsistent increase in platelet sensitivity to aggregation induced by ADP and collagen. The relative lack of effect of oestriol succinate on coagulation function is encouraging with regard to the future incidence of thromboembolic complications of therapy.
在之前的一份报告中，我们表明，在为期四个月的时间里，给绝经后女性服用琥珀酸雌三醇，与乙炔雌二醇相比，其对止血功能的影响较小。我们对使用琥珀酸雌三醇治疗骨质疏松症长达12个月的绝经后女性的潜在长期影响进行了研究。在此期间，血浆凝血因子浓度无显著变化，纤溶酶原浓度和优球蛋白溶解活性增加，血小板对ADP和胶原诱导的聚集敏感性增加但不稳定。就治疗血栓栓塞并发症的未来发生率而言，琥珀酸雌三醇对凝血功能相对缺乏影响是令人鼓舞的。
