Lakdawala D R, Widdowson E M
Lancet. 1977 Jan 22;1(8004):167-8. doi: 10.1016/s0140-6736(77)91764-0.
The vitamin-D concentration in human milk is reported to be very low, yet breast-fed infants do not develop rickets. All the earlier assays of vitamin D were made on the lipid fraction of milk, and the aqueous phase was discarded. It is now clear that most of the vitamin D in human milk is present as a water-soluble conjugate of vitamin D with sulphate. The concentration of vitamin-D sulphate in the aqueous fraction of human milk collected at different stages of lactation has been chemically measured. Milk was collected from twenty-two women 3-8 days post partum and fourteen women 4-6 weeks post partum. The vitamin-D sulphate concentration in milk collected between the 3rd and 5th days was 1-78 mug/dl, significantly higher that the 1-00 mug/dl for milk collected between the 6th and 8th days. After the 8th day there was no significant change.
据报道，母乳中的维生素D浓度很低，但母乳喂养的婴儿不会患佝偻病。早期所有维生素D的检测都是针对乳汁的脂质部分进行的，水相则被丢弃。现在已经清楚，母乳中的大部分维生素D是以维生素D与硫酸盐的水溶性结合物形式存在的。已经对在不同哺乳期收集的母乳水相部分中维生素D硫酸盐的浓度进行了化学测定。从22名产后3 - 8天的妇女和14名产后4 - 6周的妇女那里收集了乳汁。在第3天至第5天收集的乳汁中维生素D硫酸盐浓度为1 - 78微克/分升，明显高于第6天至第8天收集的乳汁中的1 - 00微克/分升。第8天之后没有显著变化。
