麦考西林，一种新型抗真菌抗生素。I. 发酵、分离及生物学特性

Mycoversilin, a new antifungal antibiotic. I. Fermentation, isolation and biological properties.

作者信息

Samanta A K, Bose S K

出版信息

J Antibiot (Tokyo). 1984 Jul;37(7):728-32. doi: 10.7164/antibiotics.37.728.

DOI:10.7164/antibiotics.37.728

Abstract

A new antifungal antibiotic, mycoversilin, was isolated from the culture filtrate of Aspergillus versicolor (N5)17 by repeated column chromatography and recrystallized from ethyl acetate as homogeneous fine needles. Maximum production took place in a medium containing 4% glucose and 1% peptone at pH 3.5, temperature 28 degrees C after 8-9 days of incubation under stationary condition. Mycoversilin is a narrow spectrum antibiotic with activity against filamentous fungi, particularly Trichophyton rubrum (MIC 15 micrograms/ml).

摘要

一种新的抗真菌抗生素——霉菌素，通过反复柱色谱法从杂色曲霉（N5）17的培养滤液中分离出来，并从乙酸乙酯中重结晶为均匀的细针状晶体。在含有4%葡萄糖和1%蛋白胨、pH值为3.5、温度为28摄氏度的培养基中，在静止条件下培养8-9天后产量最高。霉菌素是一种窄谱抗生素，对丝状真菌具有活性，尤其是红色毛癣菌（最低抑菌浓度为15微克/毫升）。