人工胰腺使血糖正常化对胰岛素依赖型糖尿病患者粒细胞吞噬和杀菌功能的影响。
Influence of glycaemic normalisation by an artificial pancreas on phagocytic and bactericidal functions of granulocytes in insulin dependent diabetic patients.
作者信息
Gin H, Brottier E, Aubertin J
出版信息
J Clin Pathol. 1984 Sep;37(9):1029-31. doi: 10.1136/jcp.37.9.1029.
Abstract
Ten insulin dependent diabetic patients were maintained in normoglycaemia for 36 h with an artificial pancreas. Circulating polymorphonuclear leucocytes were extracted and incubated with staphylococcus before and after treatment; phagocytic and bactericidal activities were studied. Granulocytes from diabetic patients showed a decreased ability to absorb staphylococcus and a reduced capacity for intracellular destruction of bacteria. These two functions were improved after 36 h of normoglycaemia but were not corrected.
摘要
10名胰岛素依赖型糖尿病患者使用人工胰腺维持正常血糖水平36小时。在治疗前后提取循环中的多形核白细胞并与葡萄球菌一起培养；研究吞噬和杀菌活性。糖尿病患者的粒细胞吸收葡萄球菌的能力下降，细胞内细菌破坏能力降低。在正常血糖水平维持36小时后，这两种功能有所改善，但未恢复正常。
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