Takashima S, Saeki H, Moriwaki S, Yamamoto Y
Gan No Rinsho. 1984 Jul;30(8):880-4.
In a survey of the thyroid glands of 621 patients with terminal malignant tumors, 50 (8.1%) were found to be associated with metastatic tumors. Examination of routine autopsy materials revealed this association in 11 out of 269 cases (4.1%); observations using multiple sections showed in this association 39 of 352 (11.1%) cases. The primary cancer sites most commonly associated with metastasis to the thyroid gland were the breast (8 of 25 cases, 32.0%), the lung (13 of 65. 20.0%), and the esophagus (3 of 16, 18.8%). Morphological observations showed the formation of regional nodules in 13 cases, diffuse infiltration into the whole thyroid gland in 17 and intravascular embolism alone in 20 patients. There changes were inferred to be due to hematogenous metastases.
在对621例晚期恶性肿瘤患者的甲状腺进行的一项调查中，发现50例（8.1%）与转移性肿瘤有关。对常规尸检材料的检查显示，269例中有11例（4.1%）存在这种关联；使用多个切片观察显示，352例中有39例（11.1%）存在这种关联。最常与甲状腺转移相关的原发癌部位是乳腺（25例中的8例，32.0%）、肺（65例中的13例，20.0%）和食管（16例中的3例，18.8%）。形态学观察显示，13例形成局部结节，17例弥漫性浸润整个甲状腺，20例仅出现血管内栓塞。这些变化被推断为血行转移所致。
