Nishigori H, Lee J W, Iwamoto Y, Hayashi R, Maruyama K, Iwatsuru M
Life Sci. 1984 Aug 27;35(9):981-5. doi: 10.1016/0024-3205(84)90664-7.
The level of hepatic lipidperoxides in chick embryos was determined during cataract formation resulting from glucocorticoid treatment. When 15 day old chick embryos were administered 0.25 mumol of hydrocortisone acetate their hepatic lipidperoxide level, determined by thio-barbituric acid, increased after a lag time of 20 hr and reached approximately 8-fold of control at 48 hr after the treatment. These studies indicate that the peroxidation of lipid in tissues should be considered in elucidating mechanisms of action or adverse effects of glucocorticoids.
在糖皮质激素治疗导致白内障形成的过程中，测定了鸡胚肝脏脂质过氧化物的水平。当给15日龄的鸡胚注射0.25μmol醋酸氢化可的松时，通过硫代巴比妥酸测定的其肝脏脂质过氧化物水平在滞后20小时后升高，并在治疗后48小时达到对照水平的约8倍。这些研究表明，在阐明糖皮质激素的作用机制或不良反应时，应考虑组织中脂质的过氧化作用。
