Taché Y, Grijalva C V, Gunion M W, Cooper P H, Walsh J H, Novin D
Neuroendocrinology. 1984 Aug;39(2):114-9. doi: 10.1159/000123966.
Electrolytic lesions of the lateral hypothalamus (LH), but not of the lateral thalamus, prevented the elevation of serum gastrin induced by intracisternal injection of bombesin in rats. Knife cuts through the lateral or the posterior LH border largely abolished the rise in circulating gastrin induced by intracisternal bombesin. Cuts through the medial LH border partly inhibited the response, whereas cuts through the anterior LH border did not modify peptide action. None of the transections altered basal gastrin levels nor the rise in gastric pH and inhibition of gastric acid output induced by intracisternal bombesin. LH lesions did not modify the rise in serum gastrin induced by intravenous bombesin. These results demonstrate that the gastrin-releasing effect of intracisternal bombesin requires the integrity of fibers crossing the posterior, lateral, and medial borders of the LH and is independent of changes in gastric pH. The LH area is not itself necessary for the expression of the inhibitory action of bombesin on gastric acid secretion.
损毁大鼠下丘脑外侧区（LH）而非丘脑外侧部的电解损伤，可阻止脑池内注射蛙皮素引起的血清胃泌素升高。切断LH外侧或后缘可在很大程度上消除脑池内注射蛙皮素引起的循环胃泌素升高。切断LH内侧缘可部分抑制该反应，而切断LH前缘则不改变肽的作用。所有横断均未改变基础胃泌素水平，也未改变脑池内注射蛙皮素引起的胃内pH升高及胃酸分泌抑制。LH损伤并未改变静脉注射蛙皮素引起的血清胃泌素升高。这些结果表明，脑池内注射蛙皮素的胃泌素释放效应需要穿过LH后缘、外侧缘和内侧缘的纤维完整，且与胃内pH变化无关。LH区本身对于蛙皮素对胃酸分泌的抑制作用表达并非必需。
