Gunion M W, Tache Y, Walsh J H, Novin D
Life Sci. 1984 Oct 22;35(17):1769-75. doi: 10.1016/0024-3205(84)90274-1.
Intracisternal administration of the tetradecapeptide peptide bombesin suppresses gastric acid release. Other studies have shown that the ventromedial hypothalamus (VMH) may have an inhibitory role in gastric regulation. To determine if the inhibition of gastric acid secretion by intracisternally administered bombesin is mediated by the ventromedial hypothalamus, bombesin was injected intracisternally in rats with ventromedial hypothalamic lesions. Neither anterior nor posterior VMH lesions altered the effects of bombesin on gastric acid, concentration, volume, total output, or on serum gastrin. The bombesin-induced rise in gastric pH was very mildly attenuated by both lesions. The previous finding of enhanced gastric acid secretion after anterior VMH lesions was confirmed. The results suggest that the VMH is not crucial in the bombesin-induced inhibition of acid secretion.
脑池内注射十四肽蛙皮素可抑制胃酸分泌。其他研究表明，腹内侧下丘脑（VMH）可能在胃调节中起抑制作用。为了确定脑池内注射蛙皮素对胃酸分泌的抑制作用是否由腹内侧下丘脑介导，对患有腹内侧下丘脑损伤的大鼠进行脑池内注射蛙皮素。VMH前部和后部损伤均未改变蛙皮素对胃酸、浓度、体积、总分泌量或血清胃泌素的影响。两种损伤均使蛙皮素引起的胃pH值升高略有减弱。先前关于VMH前部损伤后胃酸分泌增加的发现得到了证实。结果表明，VMH在蛙皮素诱导的胃酸分泌抑制中并非关键因素。
