急性下丘脑外侧损伤对胃液分泌的刺激作用及其通过脑池内注射蛙皮素的逆转作用。

Stimulation of gastric secretion by acute lateral hypothalamic lesions and its reversal by intracisternal injection of bombesin.

作者信息

Taché Y, Grijalva C V, Gunion M W, Walsh J H, Novin D

出版信息

Life Sci. 1982 Nov 29;31(22):2485-91. doi: 10.1016/0024-3205(82)90754-8.

Abstract

Lateral hypothalamic (LH) but not lateral thalamic (LT) electrolytic lesions markedly increased gastric secretion (volume and acidity) in rats within 2 h of production of the lesions and pylorus ligation. Intracisternal injection of bombesin inhibited gastric secretion (volume and acidity) and reduced to control levels the enhanced acid output produced by the LH lesions. These data demonstrate that acute LH lesions stimulate gastric secretion, and that bombesin exerts a potent gastric antisecretory influence, probably through interaction with LH-related stimulatory pathways.

摘要

下丘脑外侧（LH）而非丘脑外侧（LT）的电解损伤在损伤和幽门结扎产生后的2小时内，显著增加了大鼠的胃分泌（量和酸度）。脑池内注射蛙皮素可抑制胃分泌（量和酸度），并将由LH损伤产生的增强的酸分泌降低至对照水平。这些数据表明，急性LH损伤刺激胃分泌，并且蛙皮素可能通过与LH相关的刺激途径相互作用，发挥强大的胃抗分泌作用。